Synthesis of α-chloroamides in water

The reaction between chloroacetyl chloride and mono- or bis-aliphatic or aromatic amines in water under basic or neutral conditions gives rise to the formation of a variety of functionalized α-chloroamides. The resulting products were obtained as solids in moderate to good yields, upon precipitation and isolation by filtration.

Graphical abstractThe synthesis of mono- and bis-α-chloroamides from chloroacetyl chloride and mono or bis-amines in water in the presence of base is described. These were formed in good yields after simple filtration of the desired products. This method was particularly effective for the formation of functionalized aromatic α-chloroamides.Download full-size image