Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278467 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
The three component reaction of ethyl acetamidocyanoacetate with dialkyl acetylenedicarboxylates and triphenylphosphine leads to phosphorus ylides in good yields. These ylides undergo a 1,2-proton shift, loss of triphenylphosphine, and subsequent intramolecular amidation leads to the formation of N-acetyl α,β-unsaturated γ-lactams.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sakineh Asghari, Mahmood Tajbakhsh, Vali Taghipour,