Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278525 | Tetrahedron Letters | 2009 | 5 Pages |
Abstract
An efficient protocol for the synthesis of a new series of dithiocarbamate-linked peptidomimetics is described. The in situ-generated dithiocarbamic acid intermediate formed by the reaction of an amino acid ester and carbon disulfide in the presence of triethylamine was treated with N-protected amino alkyl iodide to afford title compounds in good to moderate yields. The protocol was also extended to synthesize dithiocarbamate-linked tripeptidomimetics, N,Nâ²-orthogonally protected dipeptidomimetics as well.
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Authors
Hosahalli P. Hemantha, Vommina V. Sureshbabu,