| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5278548 | Tetrahedron Letters | 2011 | 5 Pages |
Abstract
A simple and efficient method for the chemoselective N-Boc protection of the amine moiety in a variety of compounds is described using di-tert-butyl dicarbonate and guanidine hydrochloride as an organocatalyst in ethanol at 35-40 °C. Selective mono-N-Boc protection of diamines and chemoselective protection of hydroxylamines without formation of any side products is achieved. Amino acids and peptides are N-Boc protected efficiently in excellent yields under convenient reaction conditions.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fatemeh Jahani, Mahmood Tajbakhsh, Hamid Golchoubian, Samad Khaksar,