Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278596 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
An effective synthetic strategy for construction of the novel spiro-bicyclic β-lactone-γ-lactam system present in oxazolomycin has been demonstrated. The 3,4-disubstituted pyrrolidine ring system was constructed via an Evans aldol reaction. The spiro-β-lactone ring was elaborated from a gem-hydroxymethyl moiety that was successfully installed by an aldol followed by a crossed Cannizzaro reaction.
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