Article ID Journal Published Year Pages File Type
5278596 Tetrahedron Letters 2006 5 Pages PDF
Abstract

An effective synthetic strategy for construction of the novel spiro-bicyclic β-lactone-γ-lactam system present in oxazolomycin has been demonstrated. The 3,4-disubstituted pyrrolidine ring system was constructed via an Evans aldol reaction. The spiro-β-lactone ring was elaborated from a gem-hydroxymethyl moiety that was successfully installed by an aldol followed by a crossed Cannizzaro reaction.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry