| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5278609 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
We describe an efficient synthesis of the 14-membered macrolide core 2 of migrastatin via key intermediate 3 employing a diastereoselective aldol condensation, Lewis acid mediated diastereoselective addition and an exclusive (Z)-olefination sequence. Yamaguchi esterification of the key intermediate 3 followed by ring-closing metathesis (RCM) produced macrolide 2 with high selectivity and good yield.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
V. Sai Baba, Parthasarathi Das, K. Mukkanti, Javed Iqbal,