| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5278610 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
The reaction of a sulfonamide moiety with HBTU (O-(1H-benzotriazol-1-yl)-N,N,Nâ²,Nâ²-tetramethyluronium hexafluorophosphate) during amide coupling, leading to the formation of tetramethylsulfonylguanidines, is described. Optimised conditions showed that HBTU was as a convenient agent for the synthesis of tetramethylsulfonylguanidines, in basic conditions. A panel of diverse sulfonamides was used to demonstrate the scope of this procedure.
Graphical abstractOne pot synthesis of tetramethylsulfonylguanidines was developed using HBTU (O-(1H-benzotriazol-1-yl)-N,N,Nâ²,Nâ²-tetramethyluronium hexafluorophosphate).Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sébastien Gluszok, Laurence Goossens, Patrick Depreux, Jean-Pierre Hénichart,