Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278614 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
We report here a methodology for the construction of a conjugated cyanodiene synthon and the propensity of such synthons to participate in the olefin metathesis reaction. To this end, we have developed a strategy for the construction of the C11-C15 fragment of borrelidin and demonstrated the utility of the RCM reaction in the preparation of the final macrolide. To our knowledge, this is the first example of a RCM with a nitrile functionality on a diene.
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Physical Sciences and Engineering
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Organic Chemistry
Authors
C. Vamsee Krishna, Santanu Maitra, R. Vasu Dev, K. Mukkanti, Javed Iqbal,