Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278731 | Tetrahedron Letters | 2009 | 4 Pages |
Dicyclohexylcarbodiimide-promoted self-condensation of 2,3:4,5-di-O-isopropylidene-d-galactonic acid (3) led to the macrocyclic oligomeric cyclo[(2,3:4,5-di-O-isopropylidene-(1â6)-d-galactonate)2] (4) and cyclo[(2,3:4,5-di-O-isopropylidene-(1â6)-d-galactonate)3] (5), having, respectively, 14- and 21-membered rings. The macrocycles 4 and 5 were also synthesized by cyclization of the respective linear dimer 11 and trimer 14 Ï-hydroxy acids precursors prepared by stepwise additions of 3. Compounds 4 and 5 are biomaterials that may be described as macrolactone-cyclodextrins.
Graphical abstractMacrocyclic lactones 4 and 5 were prepared by cyclization of the respective dimer and trimer linear precursors obtained by self-condensation of the d-galactonic acid derivative 3.Download full-size image