Stereoselective synthesis of the C33-C44 fragment of palau'amide

An efficient stereoselective synthesis of the C33-C44 fragment of palau'amide is described using a Sharpless asymmetric epoxidation, a regioselective nucleophilic ring opening of the epoxide, a Grignard reaction and a Luche stereoselective reduction of a keto compound as the key steps.

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