Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278766 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
A microwave accelerated epoxide ring-opening process with N-biaryl sulfonamides is described. Under this mild, highly efficient condition, an α-hydroxy-β-N-biaryl sulfonamide skeleton is rapidly assembled leading ultimately to a novel series of matrix metalloproteinase-9 inhibitors with single digit nanomolar activities.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shyh-Ming Yang, William V. Murray,