Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278802 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
A convenient and efficient route to novel unsymmetrically disubstituted azetidin-2-ones is described. β-Lactam carbocation equivalents of type 1 and active aromatic substrates in the presence of a Lewis acid promote a facile and stereoselective C-3 substitution to provide monosubstituted β-lactams (3,4) and symmetrically disubstituted β-lactams (5). cis-3-(4â²-Methoxyphenyl)-3-phenylthioazetidin-2-ones (4) undergo further substitution with active aromatic substrates mediated by a Lewis acid to afford unsymmetrically disubstituted azetidin-2-ones (7).
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
Aman Bhalla, Suman Rathee, Sachin Madan, Paloth Venugopalan, Shamsher S. Bari,