A stereoselective synthesis of the C11-C19 fragment of (+)-peloruside A

A new route to the synthesis of the C11-C19 fragment of peloruside A is described, which includes an aldol reaction with ethyl acetoacetate, β-hydroxyl-directed reduction of β-hydroxy ketone, as well as methylation of C13 hydroxyl moiety in the system of MeI-Ag2O-MgSO4-CH2Cl2.

Graphical abstractA new route to the synthesis of the C11-C19 fragment of peloruside A is described.Download full-size image