| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5278875 | Tetrahedron Letters | 2005 | 4 Pages |
Abstract
A novel solid-phase method for the synthesis of 4-methyl-pyrido[2,3-d]pyrimidin-7-one compounds with two diversity points is described. The polymer supported methylsulfonyl derivatives A3, achieved by coupling compound G with different resin-bound amines A1 followed by oxidation with MCPBA, are substituted with several amines R1R2NH. Final cleavage affords 126 compounds having formula H in good yield and purity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Solid-phase synthesis of pyrido[2,3-d]pyrimidin-7-ones](/preview/png/5278875.png "First Page Preview: Solid-phase synthesis of pyrido[2,3-d]pyrimidin-7-ones")
Authors
Mauro Angiolini, Domenico Fusar Bassini, Markus Gude, Maria Menichincheri,