Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278884 | Tetrahedron Letters | 2005 | 4 Pages |
Abstract
The aldol-type addition of acetone towards (un)substituted benzoyl, heteroarylcarbonyl or α,β-unsaturated acyl cyanides was efficiently catalyzed by l-proline (30 mol %) to give 2-hydroxy-4-oxo-2-substituted pentanenitriles. Upon the treatment with sodium hydroxide, the adducts transformed to 1,3-diketones in good-to-excellent yield, furnishing an efficient and convenient method for the regioselective synthesis of 1,3-diketones.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zongxuan Shen, Bin Li, Lu Wang, Yawen Zhang,