| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5278915 | Tetrahedron Letters | 2011 | 6 Pages |
Abstract
The efficient palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of (2S)-isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4-one with, arylethynyl-, heteroarylethynyl-, and alkylethynyltrifluoroborate salts is reported. The standard protocol was evaluated and optimized in order to gain access to suitable precursors of enantiopure 2-substituted β-amino acids. The scope and limitations of this methodology are discussed.
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Authors
Hélio A. Stefani, Monica F.Z.J. Amaral, Eusebio Juaristi,