Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5279006 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
The nucleophilic addition of amines to Baylis-Hillman acetates has been efficiently carried out in water at room temperature in the absence of any base, acid, or metal catalyst to produce α-dehydro-β-amino esters and nitriles. This procedure addresses a variety of aliphatic open-chain and cyclic amines and anilines. All the reactions are highly regio- and stereoselective, fast and high yielding.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sudip Ghosh, Raju Dey, Kalicharan Chattopadhyay, Brindaban C. Ranu,