| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279010 | Tetrahedron Letters | 2009 | 6 Pages |
Abstract
A powerful direct reductive amination (DRA) method is developed, using catalytic MoO2Cl2 and phenylsilane (PhSiH3) as the reducing agent. The alkylation of a range of amines (pKa 0-7.8) with both an electron-deficient and two electron-rich-aldehydes is achieved in good to excellent yields. The novel employment of this DRA in alcoholic solvents significantly improves the reaction scope and excellent functional group selectivity is exhibited.
Graphical abstractA powerful direct reductive amination (DRA) method is developed, using catalytic MoO2Cl2 and with PhSiH3 as the reducing agent.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Clive A. Smith, Laura E. Cross, Kimberley Hughes, Rebecca E. Davis, Duncan B. Judd, Andrew T. Merritt,