Article ID Journal Published Year Pages File Type
5279048 Tetrahedron Letters 2005 4 Pages PDF
Abstract
A simple, clean and highly efficient solvent-free procedure for the preparation of primary, secondary, tertiary and aromatic amides is described from the direct reaction of carboxylic acids and silica-supported ammonium salts, triethylamine (TEA) and tosyl chloride (TsCl) as condensing agent. The reaction proceeds rapidly in high yields at room temperature.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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