| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279080 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
Perfluorinated chiral alcohols are interesting building blocks for pharmaceuticals and agrochemicals. Different chiral (R)- and (S)-configured perfluorinated alcohols were produced by asymmetric reduction of the corresponding ketones. Commercially available alcohol dehydrogenases were used as catalyst in combination with different cofactor regenerating systems. High selectivities of >99% were observed in most cases. The results also demonstrate the influence of the CF3 group on reactivity and enantioselectivity of alcohol dehydrogenases.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thomas C. Rosen, Ralf Feldmann, Pascal Dünkelmann, Thomas DauÃmann,