Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5279104 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
Metal iodide mediated three-component reactions of cyclopropanecarboxylic thioesters 1, aldehydes, and amines were developed. The initial products, pyrrolidines 2 were obtained in 39-73% yields, which could further be converted to lactams 4, via sequential reactions of a retro-aza-Michael addition and an intramolecular cyclization. This methodology provided facile access to analogs of both pyrrolidines 2 and lactams 4.
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Physical Sciences and Engineering
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Authors
Wenwei Huang, Janice Chin, Luke Karpinski, Gary Gustafson, Carmen M. Baldino, Libing Yu,