| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279118 | Tetrahedron Letters | 2006 | 6 Pages |
Abstract
We developed conditions to carry out the first 'one-pot' Ullmann-Finkelstein-Ullmann multicomponent reaction reported. This reaction allows the one-pot synthesis of dissymmetrical para-disubstituted benzene scaffold from 1-bromo-4-iodobenzene and two N-nucleophiles. CuI/N,Nâ²-dimethyl-cyclohexane-1,2-diamine was used as a catalyst/ligand couple, K3PO4 as a base and the reaction was performed in dioxane.
Graphical abstractThe development of a Ullmann-Finkelstein-Ullmann multicomponent reaction and its application to the synthesis of nonsymmetrical para-disubstituted benzene compounds are described.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Patrick Toto, Jean-Claude Gesquière, Nicolas Cousaert, Benoit Deprez, Nicolas Willand,