| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279131 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
1,3-Dipolar cycloaddition of alkyl glyoxylate-derived nitrones to E-crotonaldehyde can be catalyzed by hybrid diamines, obtained from (S)-BINAM and l-α-amino acids. The hybrid of (S)-BINAM and l-Phe was found to be the best organocatalyst. Products were obtained in good yield and diastereoselectivity as well as high enantioselectivity (82–91% ee). Subsequent transformations into functionalized pyrrolidinones have been demonstrated.
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