Article ID Journal Published Year Pages File Type
5279139 Tetrahedron Letters 2011 4 Pages PDF
Abstract
We synthesized the 3′-phosphoramidite building block of 4-thiopseudoisocytidine (s4ΨiC) and incorporated it into triplex-forming oligonucleotides (TFOs). The results of thermal denaturation of triplexes incorporating s4ΨiC showed that s4ΨiC could be used as a nucleoside component of TFOs to increase the thermal stability of triplexes at pH 7.
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Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
Synthesis and triplex-forming properties of oligonucleotides containing thio-substituted C-nucleoside 4-thiopseudoisocytidine
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