| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279176 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
In contrast to 2,2â²-diisopropylbiphenyl, 2-phenyl-2â²-isopropylbiphenyl, 1, and 2-cyclohexyl-2â²-phenylbiphenyl, 2, undergo racemization at room temperature. Chiral HPLC analysis on Chiralcel OD show formation of a temperature-dependent plateau between the well-resolved peaks due to simultaneous enantioseparation and on-column enantioconversion. The rotational energy barrier of these axially chiral compounds has been determined as 91.3 (1) and 91.4Â kJ/mol (2) by computer simulation of experimentally obtained HPLC elution profiles.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christian Wolf, Hanhui Xu,