| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279186 | Tetrahedron Letters | 2007 | 5 Pages |
Abstract
A convenient protocol for the rapid and efficient synthesis of 3-(N-substituted) aminocoumarins is described. The synthetic route developed involves the Pd-catalyzed C-N coupling reaction from readily available 3-bromocoumarin derivatives in the presence of the catalytic system Pd(OAc)2/Xantphos. Under these conditions, a series of nucleophiles including amides, sulfonamides, carbamates and functionalized amines, have been successfully reacted to afford the coupling products in fair to good yields.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Davide Audisio, Samir Messaoudi, Jean-François Peyrat, Jean-Daniel Brion, Mouâd Alami,