Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5279267 | Tetrahedron Letters | 2005 | 4 Pages |
Abstract
gem-Difluorinated vinyloxiranes, which are useful synthetic intermediates for difluorinated compounds, were brominated regio- and stereoselectively. Introduction of bromide at the allylic epoxide carbon with inversion of stereochemistry was realized by MgBr2·Et2O to furnish an anti vic-bromohydrine, whereas the reaction with LiBr/AcOH afforded the other diastereomer selectively. Moreover, both reactions at high temperature allowed to obtain, the thermodynamically favored products, E-allylic alcohols dominantly.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hisanori Ueki, Tomoya Kitazume,