| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279328 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
A total synthesis of LL-Z1640-2 (2), a potent and selective kinase inhibitor, has been completed. The key step of the convergent synthesis utilized a late-stage intramolecular Nozaki-Hiyama-Kishi (NHK) reaction to close the macrocycle at the C6â²-C7â² bond.
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Authors
Christopher A. LeClair, Matthew B. Boxer, Craig J. Thomas, David J. Maloney,