Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5279434 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
For the first time, a palladium complex with a porphyrin ligand is used as a catalyst precursor for cross-coupling reactions. The synthesis of a palladium complex with a phosphine-free and water-soluble potassium carboxylate salt of a porphyrin, and its evaluation in the Suzuki-Miyaura reaction of phenylboronic acid with aryl bromides (from electron-rich to electron-poor), in neat water, under aerobic conditions is described. Catalysis is performed at 100 °C for 4 h, using K2CO3 as base, and a substrate to catalyst molar ratio of 1000:1, leading to yields of coupling products in the range of 80-100%. The catalyst can be recycled and reused, but unfortunately, with a loss in activity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ioannis D. Kostas, Athanassios G. Coutsolelos, Georgios Charalambidis, Aggeliki Skondra,