| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279442 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A diastereodivergent synthesis of enantiopure cis- and trans-2-[(3-ethyl-4-piperidyl)methyl]indole (cis-1b and trans-1b) from a common phenylglycinol-derived oxazolopiperidone lactam 3 is reported. The key step is a stereocontrolled conjugate addition, either under kinetic or thermodynamic control, of the dilithium salt of 2-(2-indolyl)-1,3-dithiane to unsaturated lactam 3.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Enantioselective synthesis of 2-[(3-ethyl-4-piperidyl)methyl]indoles from a phenylglycinol-derived lactam: formal synthesis of Strychnos alkaloids](/preview/png/5279442.png "First Page Preview: Enantioselective synthesis of 2-[(3-ethyl-4-piperidyl)methyl]indoles from a phenylglycinol-derived lactam: formal synthesis of Strychnos alkaloids")
Authors
Mercedes Amat, Núria Llor, Begoña Checa, Maria Pérez, Joan Bosch,