| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279444 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A procedure for the enantioselective alkylation of indole at the 2-position with simple non-chelating enones is described for the first time. Reaction between 4,7-dihydroindole and enones in the presence of zirconium(IV)-BINOL complexes, followed by a p-benzoquinone oxidation gives indoles alkylated at the 2-position with good yields and moderate enantioselectivities.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gonzalo Blay, Isabel Fernández, José R. Pedro, Carlos Vila,