| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279456 | Tetrahedron Letters | 2007 | 6 Pages |
Abstract
A convenient and efficient one-pot preparation of nitriles from alcohols using N-(p-toluenesulfonyl)imidazole (TsIm) is described. In this method, treatment of alcohols with a mixture of NaCN, TsIm and triethylamine in the presence of catalytic amounts of tetra-n-butylammonium iodide (TBAI) in refluxing DMF furnishes the corresponding alkyl nitriles in good yields. This methodology is highly efficient for various structurally diverse alcohols with selectivity for ROH: 1° > 2° > 3°.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mohammad Navid Soltani Rad, Ali Khalafi-Nezhad, Somayeh Behrouz, Mohammad Ali Faghihi,