| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279480 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
The methylsulfonylethoxycarbonyl (Msc) group is presented as a non-lipophilic, base-labile, participating protecting group for carbohydrate alcohols. It can be introduced using Msc-Cl and pyridine and is readily cleaved via β-elimination under mild basic conditions. Its fluorous counterpart, the perfluorooctyl propylsulfonylethoxycarbonyl (FPsc) group, is used in a 'light fluorous' trisaccharide synthesis sequence.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Asghar Ali, Richard J.B.H.N. van den Berg, Herman S. Overkleeft, Dmitri V. Filippov, Gijsbert A. van der Marel, Jeroen D.C. Codée,