Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5279491 | Tetrahedron Letters | 2009 | 4 Pages |
C2-symmetric bis(sulfonamide) ligands derived from chiral trans-(1R,2R)-cyclohexane-1,2-diamine were immobilized on silica gel and on polystyrene resin, and complexed to RhIIICpâ. The resulting complexes were used as catalysts in the asymmetric transfer hydrogenation (ATH) of acetophenone. The chiral secondary alcohol was obtained in high yields (>99%) and enantioselectivities (92%) with aqueous sodium formate as the hydride source. The immobilized catalysts were recycled with no loss in activity.
Graphical abstractC2-symmetric bis(sulfonamide) ligands derived from chiral trans-(1R,2R)-cyclohexane-1,2-diamine were immobilized on silica gel and complexed to RhIIICpâ. The resulting complexes act as catalysts in the asymmetric transfer hydrogenation (ATH) of acetophenone.Download full-size image