Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5279542 | Tetrahedron Letters | 2005 | 4 Pages |
Abstract
A novel method for effecting the aza-Michael reactions of N-alkyl- and N-arylpiperazines with acrylonitrile using Cu-nanoparticles is described. The method features the use of 10 mol % Cu (14-17 nm) nanoparticles under mild reaction conditions to afford the addition products in good to excellent yields. The Cu-nanoparticles selectively catalysed the aza-Michael reaction of N-alkyl- and N-arylpiperazines in the presence of aromatic amino or aliphatic hydroxy groups.
Graphical abstractCu-nanoparticles, 14-17Â nm in size, efficiently catalyse the Michael-type reaction of N-alkyl- and N-arylpiperazines with acrylonitrile in high yield under mild reaction conditions.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Akhilesh K. Verma, Rupesh Kumar, Preeti Chaudhary, Amit Saxena, Ravi Shankar, Subho Mozumdar, Ramesh Chandra,