| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279562 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
The regioselective aminoethylation of 1,4-benzodiazepin-2-one 1 can be carried out using classical heating or microwave irradiation as the source of energy to furnish either N-1 or N-4 aminoethylated products 2a-d and 3a-d, respectively. The regioselectivity observed has been rationalized using computational studies and has been traced to the disparity of the rate-determining steps along the N-1 product (N-1 PR) and N-4 product (N-4 PR) formation pathways.
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Related Topics
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Authors
Jitendra Kumar Mishra, J. Srinivasa Rao, G. Narahari Sastry, Gautam Panda,