| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279569 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
The isolation and structure elucidation of belamide A from the marine cyanobacterium Symploca sp. is described. Belamide A is a highly methylated linear tetrapeptide with structural analogy to the important linear peptides dolastatins 10 and 15. Disruption of the microtubule network in A-10 cells was observed at 20 μM and displayed classic tubulin destabilizing antimitotic characteristics. The moderate cytotoxicity of belamide A (IC50 0.74 μM vs HCT-116 colon cancer line) provides new insights into structure-activity relationships for this drug class.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
T. Luke Simmons, Kerry L. McPhail, Eduardo Ortega-BarrÃa, Susan L. Mooberry, William H. Gerwick,