Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5279584 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
The binuclear chiral (salen) Co complexes bearing Lewis acids of Al and Ga catalyze regio- and enantioselective ring opening of terminal epoxides with carboxylic acids. The ring opened product of epichlorohydrin with carboxylic acids followed by cyclization step in the presence of catalyst and base represent straightforward, efficient methods for the synthesis of enatiomerically enriched (>99% ee) valuable terminal epoxides. Strong synergistic effects of different Lewis acid of Co-Al and Co-Ga were exhibited in the catalytic process.
Graphical abstractThe heterometallic chiral (salen) Co complexes catalyze ring opening of terminal epoxides with carboxylic acids in a regio- and enantioselective manner.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wenji Li, Santosh Singh Thakur, Shu-Wei Chen, Chang-Kyo Shin, Rahul B. Kawthekar, Geon-Joong Kim,