Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5279609 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
The reaction of α-tosyloxy ketones, sodium azide, and terminal alkynes in presence of copper(I) in aqueous polyethylene glycol afforded regioselectively 1,4-disubstituted 1,2,3-triazoles in good yield at ambient temperature. The one-pot exclusive formation of 1,4-disubstituted 1,2,3-triazoles involves in situ formation of α-azido ketones, followed by cycloaddition reaction with terminal alkyne. The generality of this one-pot method was demonstrated by synthesizing an array of diverse 1,4-disubstituted 1,2,3-triazoles.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dalip Kumar, V. Buchi Reddy, Rajender S. Varma,