Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5279688 | Tetrahedron Letters | 2005 | 4 Pages |
Abstract
Reaction of an appropriate ortho-halo tosylate precursor with organolithium reagents provides the first conclusive route to the intermediate, 7,8-quinolyne. The transient existence of this hetaryne was confirmed by Diels-Alder reactions with furan derivatives that provide endoxide adducts. Chemical induced rearrangement of these adducts allows entry to key compounds of 10-hydroxy[h]benzoquinoline and its 7-substituted derivatives in modest yields.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gavin E. Collis, Anthony K. Burrell,