Cyclization/acylation reactions by nickel-catalyzed reactions of 1,6-ynal and 1,6-enyne derivatives with acylzirconocene chloride

NiCl2(PPh3)2-catalyzed reactions of 1,6-ynal or 1,6-enyne compounds with n-nonanoylzirconocene chloride afforded stereoselectively cyclopentane derivatives or bicyclo[3.1.0] compounds by catalytic cyclization/acylation reactions, which would involve (i) the primary formation of a metallacycle followed by (ii) the transfer of an acyl group from the acylzirconocene complex (transmetalation).

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