Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5279834 | Tetrahedron Letters | 2005 | 4 Pages |
Abstract
Domino Michael reactions of oxophorone and its derivatives 4 with Michael partners 3 have been effected to give bicyclo[2.2.2]octane-2,5-dione derivatives 7 by a catalytic amount of a Brønsted base (NMAP-Li) generated from N-methylaminopropylated silica gel (NMAP) and n-BuLi. The NMAP pellets were efficiently reused up to six times in 86% average yield.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masakazu Fukushima, Satoru Endou, Takashi Hoshi, Toshio Suzuki, Hisahiro Hagiwara,