| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279895 | Tetrahedron Letters | 2009 | 6 Pages |
Abstract
A one-pot, two-step synthesis protocol for the conversion of Biginelli 3,4-dihydropyrimidin-2(1H)-thiones to 2-(2-hydroxy-2-arylvinyl) dihydropyrimidine (DHPM) derivatives via Eschenmoser sulfide contraction coupling is described. Solution phase as well as solid-supported protocol was carried out for the decoration of the Biginelli DHMP scaffold at the C-2 position. The scope of the optimized protocol is demonstrated for different DHMP precursors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sukhdeep Singh, Andreas Schober, Michael Gebinoga, G. Alexander GroÃ,