| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5279909 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
A formal total synthesis of the benzothiophene selective estrogen receptor modulator (SERM) desketoraloxifene and analogs has been accomplished from alkynes bearing electron-rich aromatic rings by electrophilic cyclization using I2. This approach affords oxygen-bearing 3-iodobenzo[b]thiophenes in excellent yields, which are easily further elaborated using a two-step approach involving Suzuki-Miyaura and Mitsunobu coupling reactions.
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Organic Chemistry
![A new approach to desketoraloxifene analogs from oxygen-bearing 3-iodobenzo[b]thiophenes prepared via iodocyclization](/preview/png/5279909.png "First Page Preview: A new approach to desketoraloxifene analogs from oxygen-bearing 3-iodobenzo[b]thiophenes prepared via iodocyclization")
Authors
Chul-Hee Cho, Dai-Il Jung, Richard C. Larock,