Organocatalytic and direct asymmetric vinylogous Michael addition of 3-cyano-4-methylcoumarins to α,β-unsaturated ketones

The first highly regio-, chemo-, and enantio-selective direct vinylogous Michael addition of 3-cyano-4-methylcoumarin derivatives to α,β-unsaturated ketones is described, employing readily available 9-amino-9-deoxy-epiquinine as the iminium organocatalyst.

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