Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5280007 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A series of compounds related to combretastatin A-4 has been synthesized by a tandem Heck-carbocyclization/Suzuki coupling process. From various alkynamides and 3,4,5-trimethoxyphenyl boronic acid or the corresponding styryl derivative, (E)-3-arylmethyleneoxindoles (type I) and (EE)-3-alkylideneoxindoles (type II) were efficiently obtained in a stereoselective manner. Factors influencing yield and stereoselectivity are detailed.
Graphical abstractAn efficient synthesis of (E)-3-arylmethyleneoxindoles (type I) and (EE)-3-alkylideneoxindoles (type II) have been developed from various anilides.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Martin Arthuis, Renée Pontikis, Jean-Claude Florent,