| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5280027 | Tetrahedron Letters | 2005 | 4 Pages |
Abstract
Phytic acid is enzymatically catabolized to numerous inositol polyphosphates and subsequently to myo-inositol and inorganic phosphate. These conversions are important in energy metabolism, metabolic regulation, and signal transduction pathways. A concise synthesis of phosphatase-resistant analogues of phytic acid (InsP6) is described in which the P-1 phosphate has been replaced by phosphorothioate, phosphoroselenate, or methylphosphonate moieties. In addition, a new synthesis of P-1 tethered aminoalkyl InsP6 and the corresponding affinity resin are described.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yong Xu, Xiao-hui Liu, Glenn D. Prestwich,