Article ID Journal Published Year Pages File Type
5280068 Tetrahedron Letters 2007 4 Pages PDF
Abstract

We report herein a concise and biomimetic synthesis of a precursor of barrenazine A, a cytotoxic alkaloid. The C2-symmetry of this molecule suggested the dimerization of an aminoketone, as the precursor of the central core pyrazine. This compound was prepared by assembly of aspartic acid and glycine.

Graphical abstractAn analogue of barrenazine A was prepared in eight steps with a 29% overall yield, from protected aspartic acid.Download full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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