Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5280068 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
We report herein a concise and biomimetic synthesis of a precursor of barrenazine A, a cytotoxic alkaloid. The C2-symmetry of this molecule suggested the dimerization of an aminoketone, as the precursor of the central core pyrazine. This compound was prepared by assembly of aspartic acid and glycine.
Graphical abstractAn analogue of barrenazine A was prepared in eight steps with a 29% overall yield, from protected aspartic acid.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Frédéric Buron, Alain Turck, Nelly Plé, Laurent Bischoff, Francis Marsais,