Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5280094 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
The sequential reactions of 2-C-methyl-d-arabinose with cyanamide and methyl propiolate afford an anhydronucleoside, which may be opened under acid conditions with inversion at C2â², to give 2â²-C-methyl uridine; ring opening with sodium hydroxide gave 2â²-C-methyl arabino-uridine with retention of configuration at C2â². This gives complete stereospecific control to yield only β-nucleosides.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sarah F. Jenkinson, Nigel A. Jones, Adel Moussa, Alistair J. Stewart, Thomas Heinz, George W.J. Fleet,