| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5280232 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
Oxidation of (5R,6S)-5,6-dihydro-5,6-dihydroxythymidine (thymidine glycol) with sodium periodate efficiently produced N-(2-deoxy-β-d-erythro-pentofuranosyl)formamide, a hydroxyl radical-induced decomposition product of pyrimidine bases in DNA, and this method was successfully applied to the conversion of thymine glycol in oligonucleotides into the formamide lesion.
Graphical abstractOxidation of thymidine glycol with sodium periodate efficiently produced N-(2-deoxy-β-d-erythro-pentofuranosyl)formamide. This method was successfully applied to the conversion of thymine glycol in oligonucleotides into the formamide lesion.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
Tatsuya Toga, Junpei Yamamoto, Shigenori Iwai,